The University of Rochester Cancer Center has developed and continues to use a Matrix Management Model to accomplish its specific goals, which include: (1) Development of a Community Based Treatment and Clinical Research Program in Monroe County, (2) Development of an Outreach Program in the adjoining eight counties of the Genesee-Finger Lakes Health Systems Area, (3) Development of a Comprehensive Cancer Education Program, (4) Development of a focused Basic Research Program emphasizing Biochemical Genetics, Biochemical Radiopharmacology, and (5) Effective participation in the National Cancer Institute above and beyond the Cancer Centers Program. The integrating research theme of the Center is the comparative study of damage and repair of macromolecules and organelles (DNA, RNA, and membranes) critical to cell survival and to an understanding of cancer cause and prevention and the design of new treatments.